Equinox Pharma is a computationally-driven logic-based drug discovery company which, in partnership with pharma companies, agrochemical companies, biotechs and medicinal chemistry-based contract research organizations, uses its capability in proprietary logic-based machine learning and chemoinformatics (INDDEx™), based on the patented SV-ILP method , to undertake drug discovery programmes for its clients.
Equinox Pharma uses its proprietary logic-based machine-learning technique INDDEx™ (Investigational Novel Drug Discovery by Example) to learn from a training dataset of active and inactive molecules from a screening programme to generate quantitative logic-based rules. These rules are in the form of pairwise distances between fragments of substructure, which provide vital chemical insight into the stereochemical and structural requirements for biological activity.
In contrast to other database screening tools, INDDEx™ is unique in the approach used such that the new structures identified, and predicted to be active, can bear little resemblance to the training data molecules. In this way INDDEx™ is a leading tool in scaffold-hopping technology.