The analysis of nanoparticles in a solution is a crucial step for a wide range of research fields commonly including polymer particles and vesicles for drug delivery systems, such as liposomes and polymersomes. Particle sizing and compositional analysis is typically achieved by combining a range of laser-based diffraction and spectroscopic techniques but these multiple methods vary in sample requirements, such as concentration, preparation, and sensitivity, which can severely affect their function and applicability.
The SPARTA system is based on a high-end confocal Raman spectroscopy set-up where the laser, camera and spectroscope are simultaneously controlled via custom, in-house MATLAB scripts, for automated single particle trapping and Raman spectral acquisition.
The SPARTA platform is ideally suited to polymer and lipid systems but can be extended to a wide range of particle formulations with unique vibrational spectra.
The complimentary information obtained from this multifaceted platform, regarding particle composition, functionalisation, size and dynamics, has enormous potential to critically impact fields including drug development and delivery, materials science, and cellular biology.