A flexible and selective approach to nanopore protein screening for accurate detection of multiple analytes. The invention utilises single-stranded oligonucleotide aptamers conjugated to double stranded DNA (dsDNA) molecular carrier. In the invention, aptamer sequences are extended to hybridise to a complementary DNA carrier, together forming a specific detection probe. Advantageously, the carrier is generic and can be used in all situations, while the aptamer is specific to the target protein.
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