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SPARTA: Single Particle Automated Raman Trapping Analysis

A comprehensive nanoparticle analysis platform based on Raman spectroscopy providing simultaneous size, composition and functionalisation analysis as well as allowing monitoring of dynamic reactions occurring the surface of individual particles.

Biomimetic osteochondral scaffold

A novel multi-laminar and anisotropic osteochondral scaffold has been developed and preliminary in vivo data obtained. This scaffold mimics the natural structure of articular cartilage, which is a highly organized, fibre-reinforced tissue with specific mechanical and biological properties.

Novel phage/AAV delivery vector for gene therapy, medical imaging and vaccine delivery

The present invention relates to a novel DNA delivery vector for targeted gene therapy, medical imaging and vaccination with increased efficacy over existing technologies. The platform comprises a phagemid hybrid with phage and recombinant adeno-associated virus (AAV) components.

Novel large-scale method of production of AAVs

A novel viral delivery vector with scope for more cost-effective commercial production over existing technologies. The platform comprises a phagemid hybrid with recombinant adeno-associated virus (AAV) components.

Vibration Defence Structure Using Seismic Metamaterials

A new solution to prevent seismic waves and ground vibration from harming buildings and structures

Novel transcriptome biomarkers for TB

GBP6 and BATF2 have been identified as novel, highly specific and sensitive biomarkers for TB and determination of their expression levels in peripheral blood can distinguish active TB from latent TB or uninfected individuals.

Serum test to differentiate Sarcoidosis from Tuberculosis

In-patient ratios of two protein biomarkers found in blood serum (CSF1R for SA and S100A8/A9 for TB) can provide excellent differential diagnosis of Sarcoidosis versus Tuberculosis, with potential for development into a low-cost, reliable ELISA-based diagnostic test.

Novel multifunctional bacteriophages

Researchers at Imperial College London have developed two novel modifications of bacteriophages to significantly improve their efficacy as vectors for targeted gene therapy, and exploit their advantages over eukaryotic viral vectors.

MicroRNA plasma markers for preterm labour

Suite of microRNAs for predicting cervical shortening and preterm birth that can be measured from blood samples taken in early pregnancy (from gestation week 12 onwards).

Novel protein fragment of von Willebrand’s factor for treating VWD and haemophilia A

Novel truncated fragments of von Willebrand factor (VWF) engineered by a team at Imperial College London.

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